well basically the angle of the bores puts strain on the rotating assembly, and the way the V6 is setup isnt ideal for big revs for a long time
basically too many revs and the strain the pistons put on the bores makes them want to blow holes in the cylinder walls and make the pistons say hello to the fresh air and daylight
i think ive read somewhere that a smaller degree angle block is better for revs as there isnt as much sideways force
probably why inline 4 cylinders can rev to 9,000 revs or more as they are vertical bores
so basically work out what power you want from the motor and what revs the power will be made at and work off of that
if the revs will be too high then look into another way of generating the power like supercharging or turbo setup