Yeah they REALLY don't like being in the wrong spot or orientation. When I first did the sequential injection conversion to my 304 I couldn't figure out what was wrong.
I had the maf rotated 90 degrees from the factory position and there was an elbow in the intake immediately before the MAF on the airbox side. Fixed those problems and it was a different car. It idled well, had good fuel economy and actually had power. Couldn't believe the difference it made. The MAF calibration in the tune relies on the factory MAF position. If you change MAF position - it'd really need to be retuned to compensate for that.
Basically, the sensor or 'hot wire' is in the centre of the maf and relies on airflow being consistent through the entire CSA of the MAF. If there's more air flowing though one section of the maf than another, that's where you have problems because the pcm doesn't know that there's extra air entering the inlet because it relies largely on MAF data for fulling calculation. Thing with MAF based systems is that they measure the ACTUAL air that enters the engine, and it's not just a calculation of air intake like a MAP based system.