joking about drinking it and eating it lol, but i do wear full airwash, gloves and spray suit when using 2k's. the prep bays we have at work are pretty good as well. all materials get sucked into the floors either sanding or spraying primer. no overspray clouds in the shop so thats good.
im not worried, theres plenty of custom painters still around, kosmoski (HOK paints) has been doing it from 1956 till now. he even manufactured his own pigments for years and dealt with some pretty gnarley chemicals along the way. as long as you wear your PPE (personal protective equipment) and handle it with common sense you should be fine. on top of that the people on the forum doing maybe 1 or 2 hobby paint jobs a year have even less to worry about, its not a full time exposure thing.
that being said i take the same precautions with 1k as i do 2k paint. regardless if it has iso in it or not, that **** is still bad for your health so i wouldnt get complacent because you think its less harmful.