Given that the Formula Holden engines make 280-300BHP using the standard V6 t'body and inlet manifold (matched to ported heads), I also question the value of swapping on a larger t'body at all. There may be a small reduction in friction due to the increased area, provided that new airflow losses aren't generated by introducing a step in the intake path. That would be covered by the posts about matching the manifold to the t'body.
Having said that, the rules for sizing a t'body on EFI engines are different to those for carbs, where a venturi vacuum is required for fuel metering. Beyond driveability issues, readily addressed with pedal/cam geometry, I can't see that it is possible to go too big with a t'body on an engine with EFI, solely looking at power output.
The downside of fitting a larger t'body to an auto trans car, as has been mentioned in another thread, is that the auto. shift control relies on throttle position as one of the inputs. Changing the relationship between the throttle angle and airflow screws with the gear changes.