I've got an MSE. Doesn't get driven much. Last time probably 4-5 weeks ago. At that time, the key I normally use was starting to show indications of a flat battery. tested the battery in that remote and it was borderline 3v. Car was reporting that it didn't detect the remote so drove it by inserting the key in the console slot.
Tonight I tried the spare key which had a flat battery so I replaced the battery with a fresh one. Did also replace the battery in the key I normally use too. Both remote keys do not unlock the car. No response whatsoever using either. Not sure what to do next. Car is due for a service shortly so not sure whether this will involve unplanned for expense.
Update. It was driving me bonkers that both keys wouldn't work even with new batteries. So I pulled the newly installed battery out of one of them to have a closer look at the battery contacts. Seeing that the positive contact for CR2032 batteries in these keys relies on touching the outer edge of the positive terminal of the battery I figured that that the contacts in the keys had possibly lost a little tension resulting in unsatisfactory contact. So after carefully bending both positive contacts just a tiny amount in towards the centre of the battery location so that they would make better contact with the outer edge of the positive side of the battery, reinstalling the fresh battery, and what do you know, the key works fine. Traps for young players. Will do the same with the spare key now.
Not sure how sustainable this fix is if the positive contacts have lost a little of their spring tension.