No. These PCM's use an injector constant (it knows how much the injector flows) and then using the MAF (to measure how much air is entering the engine) it calculates how much injector pulse width is required to achieve the target air fuel ratio.
For things like starting the PCM just has a table that tells it how much fuel to inject depending on engine temp, voltage, rpm etc. All these constants will be wrong for the larger injectors and will need adjustment.
IIRC standard 777 injectors (used in the ecotec motors from VT onward) flow 22lbs/hr. Those Super6 injectors flow 36lbs/hr so basically you are injecting about %38 more fuel than is required.
edit: fixed my bad maths....