Regardless of whether you use this sensor/cable or not, you will need a tune. Without the cable you will need a tune to run E85, but you can only use E85 from then on. With the Sensor/cable, you will still need a tune, but a different tune that allows the engine to adjust parameters automatically based on the amount of ethanol detected in the fuel.
It may not be as simple as just a tune.
From what I understand, alcohol plays havoc with hoses, seals, and possibly engine internals so it may be that a LS3 V8 engined SS could potentially require updates to fuel pump, fuel hoses, fuel seals, maybe even valve seats as well as the addition of flex fuel sensor and a retune for the LS3 to be work with a variation of alcohol content up to E85.
So does anyone categorically know if the LS3’s were built with E85 compliant fuel system so that just the addition of the flex fuel sensor and tune is all that is required?